Detailansicht
Serotonieric system, SNP's and epigenetic markers, in the control of appetite and satiety
Caroline Brettfeld
Art der Arbeit
Masterarbeit
Universität
Universität Wien
Fakultät
Fakultät für Lebenswissenschaften
Betreuer*in
Alexander Haslberger
DOI
10.25365/thesis.16786
URN
urn:nbn:at:at-ubw:1-30423.87283.560769-0
Link zu u:search
(Print-Exemplar eventuell in Bibliothek verfügbar)
Abstracts
Abstract
(Englisch)
Are you aware of your inner power system?
An immense power is shaping your inner world – your experience and conception of life. You are altering your brain chemistry, manipulating your neurochemical profile and affecting your body’s physiology every day by what you do and don’t eat, what you think, and how and where you spend your time. Through your daily behavior and the environments in which you live, you create and shape your biochemical profile. This in turn is reflected in your emotions, energy, thoughts, actions, and psychological condition that either bring out your peak performance or that block your optimal functioning or even can cause sickness.
The unbalanced homeostasis of serotonin in the body is often attributed to anxiety, depression, panic attacks, insomnia, obesity, fibromyalgia, eating disorders, chronic pain, migraines, and alcohol abuse.
My thesis “Serotonieric system - SNP`s and epigenetic markers - in the control of appetite and satiety” describes not only a very complex subject in itself but also how it affects and interacts with a huge number of inner systems and pathways.
The thesis is structured in 5 chapters:
The first two chapters provide an overview over the most recent and significant research and contain important definitions and information.
The first chapter is concerned with the genetic and epigenetic markers which are associated with obesity and how genetic and epigenetic “talk” to each other.
The second chapter reviews our scenery of investigation: the serotonic system: how is it influenced in regard to weight gain or loss. Here, not only the single receptors are closely observed but also other possible factors that potentially have an impact on appetite or satiety.
The third and forth chapters contain the practical part of the thesis. They provide the rationale and procedures of my argumentation. Consequently, the third chapter discusses the methodology of meta-analysis, its potential, complexity and limitation. The forth chapter is the meta-analysis of the HTR2C polymorphism (-759 C/T) to obesity itself. The result of the analysis can be summarized in the realization that the genetic variation alone only has a borderline significance to obesity. Therefore other possibilities must be considered in further research, for instance a special selection of different polymorphisms or, most plausibly, the effect of epigenetic markers and environmental triggers that influence us during our entire life.
For that reason the fifth chapter is entirely dedicated to epigenetic and again, very shortly, genetic markers at the serotonic receptors and environmental exposure, introducing also personal life style choices that influence our eating behavior.
Epigenetic research - still at its very early stage - opens a vast and exciting new dimension. A vast amount of scientific research is required to begin harnessing its staggering potential.
Schlagwörter
Schlagwörter
(Deutsch)
Serotonin SNP's Epigenetic
Autor*innen
Caroline Brettfeld
Haupttitel (Englisch)
Serotonieric system, SNP's and epigenetic markers, in the control of appetite and satiety
Paralleltitel (Deutsch)
Das serotonische System - SNP's und epigenetische Marker - im Bezug auf Appetit
Publikationsjahr
2011
Umfangsangabe
87 S. : Ill., graph. Darst.
Sprache
Englisch
Beurteiler*in
Alexander Haslberger
Klassifikation
30 Naturwissenschaften allgemein > 30.00 Naturwissenschaften allgemein: Allgemeines
AC Nummer
AC08846939
Utheses ID
15042
Studienkennzahl
UA | 066 | 838 | |